Rossa V, Sundmacher R, Heering P
Univ.-Augenklinik Düsseldorf.
Klin Monbl Augenheilkd. 1990 Dec;197(6):466-9. doi: 10.1055/s-2008-1046313.
Systemic cyclosporin A prophylaxis was applied in 18 high-risk corneal transplants. Immunoreactions occurred in three cases. They correlated with too low serum level of cyclosporin A. Two of them could be reversed by an increase of cyclosporin A dosage in combination with an intensive corticosteroid therapy. Four corneal transplants failed from persistent severe basic disease. Eleven corneal transplants remained clear during the follow-up (5-33 months). A constant trough cyclosporin A serum level of 100-120 ng/ml has been shown to exert efficient immunomodulating effects. We currently judge a postoperative prophylaxis period of 6 to 12 months with cyclosporin A to be sufficient in most high-risk cases.
对18例高危角膜移植患者应用全身环孢素A预防。3例发生免疫反应。它们与环孢素A血清水平过低相关。其中2例通过增加环孢素A剂量并联合强化皮质类固醇治疗得以逆转。4例角膜移植因持续性严重基础疾病而失败。11例角膜移植在随访期间（5 - 33个月）保持透明。已表明环孢素A血清谷浓度持续保持在100 - 120 ng/ml可发挥有效的免疫调节作用。我们目前认为，在大多数高危病例中，术后使用环孢素A进行6至12个月的预防期就足够了。
