Watson P G, Richardson E
Addenbrooke's Hospital Cambridge.
Klin Monbl Augenheilkd. 1994 Nov;205(5):280-3. doi: 10.1055/s-2008-1045529.
Forty nine keratoplasties were performed in 18 eyes of 17 patients with severe corneal destructive disease.
One eye became phthisical and 5 others lost useful visual acuity but retained a satisfactory cosmetic result. No eyes were enucleated. Recurrence of the host disease in the graft was the largest cause of visual failure. Primary allograft rejection was rare in spite of the large size of the grafts and their proximity to the limbus and new vessels.
For these grafts to succeed it is essential to bring the underlying systemic disease under control by intensive systemic immunosuppressive therapy before, during and for many months after surgery. It was found that those with Mooren's ulcer had the worst prognosis for the retention of vision.
对17例患有严重角膜破坏性疾病的患者的18只眼睛进行了49次角膜移植手术。
1只眼睛萎缩，另外5只眼睛失去了有用的视力，但保留了令人满意的外观效果。没有眼睛被摘除。移植片中宿主疾病的复发是视力丧失的最大原因。尽管移植片尺寸较大且靠近角膜缘和新生血管，但原发性同种异体移植排斥反应很少见。
为使这些移植成功，在手术前、手术期间及手术后数月通过强化全身免疫抑制治疗控制潜在的全身性疾病至关重要。发现患有蚕蚀性角膜溃疡的患者视力保留的预后最差。
