Benckert Christoph, Quante Markus, Jonas Sven
Klinik für Viszeral-, Transplantations-, Thorax- und Gefäßchirurgie; Universitätsklinikum Leipzig, Leipzig.
Z Evid Fortbild Qual Gesundhwes. 2010;104(5):397-9. doi: 10.1016/j.zefq.2010.06.015. Epub 2010 Jul 2.
Solid organ transplantation is one the most successful medical innovations of the 20th century. Due to an increasing number of patients on the waiting lists for transplantation in the context of persisting organ shortage the aim of optimal allocation policy is the best possible balance between medical urgency and postoperative outcome. Because of scientific evolution and increasing waiting list mortality the allocation system for liver transplantation was altered in December 2006. As intended, the preferential treatment of sicker patients resulted in a reduced waiting list mortality. On the other hand, an unintentional decrease in postoperative survival was observed. This obvious imbalance between medical urgency and postoperative outcome has led to the current allocation problem. Several scientific approaches for optimising allocation policy will be presented and discussed in this paper. Finally, continuous review and adaptation will be a persisting challenge for people working in the field of solid organ transplantation.
实体器官移植是20世纪最成功的医学创新之一。由于在器官持续短缺的情况下,等待移植的患者数量不断增加,优化分配政策的目标是在医疗紧迫性和术后结果之间实现尽可能好的平衡。由于科学的发展和等待名单上死亡率的上升,肝移植分配系统于2006年12月进行了调整。正如预期的那样,对病情较重患者的优先治疗降低了等待名单上的死亡率。另一方面,观察到术后生存率意外下降。这种医疗紧迫性和术后结果之间明显的不平衡导致了当前的分配问题。本文将介绍并讨论几种优化分配政策的科学方法。最后,持续审查和调整将是实体器官移植领域工作人员面临的持续挑战。