Träger S, Forster M, von Hodenberg E
Medizinische Klinik, Universität Heidelberg, Heidelberg.
Klin Wochenschr. 1990;68 Suppl 22:123.
Aim of the study was to analyze postprandial lipid changes after an oral fat load (400 g cream) in normal probands (n = 15). In addition we studied the uptake of postprandial VLDL by macrophages. Whereas total cholesterol (Chol), and HDL-chol did not change, plasma triglycerides (TG) (from 91 +/- 37 to 181 +/- 80 mg/dl) and VLDL-TG (from 27 +/- 18 to 41 +/- 26 mg/dl) increased significantly, with a maximum at 3 h after the oral fat load. These changes were interindividually very different and depended neither on lipoprotein or hepatic lipase levels, nor on basic lipid levels. Different post-prandial VLDL-fractions, isolated before or 3 and 6 h after the fat load caused a comparable lipid accumulation in macrophages. It seems very likely that also postprandial lipid elevations may play a role in foam cell generation.
本研究的目的是分析正常受试者（n = 15）口服脂肪负荷（400 g 奶油）后的餐后血脂变化。此外，我们还研究了巨噬细胞对餐后极低密度脂蛋白（VLDL）的摄取情况。总胆固醇（Chol）和高密度脂蛋白胆固醇（HDL-chol）没有变化，而血浆甘油三酯（TG）（从91±37增至181±80 mg/dl）和极低密度脂蛋白甘油三酯（VLDL-TG）（从27±18增至41±26 mg/dl）显著升高，在口服脂肪负荷后3小时达到峰值。这些变化个体间差异很大，既不依赖于脂蛋白或肝脂酶水平，也不依赖于基础血脂水平。在脂肪负荷前、后3小时和6小时分离的不同餐后极低密度脂蛋白组分，在巨噬细胞中引起了相当的脂质积累。餐后血脂升高很可能也在泡沫细胞生成中起作用。
