Duran N E, Oğuz E, Duran I, Aykan A C, Ertürk E, Bayram Z, Gürsoy M O, Biteker M, Karavelioğlu Y, Kaya H, Ozkan M
Kartal Kosuyolu Heart and Research Hospital Cardiology, Istanbul, Turkey.
Phlebology. 2010 Oct;25(5):246-51. doi: 10.1258/phleb.2009.009040.
The relationship between venous thrombosis (VT) and atherosclerosis is controversial in recent studies. Aortic elastic properties have a predictive value in detecting early stages of atherosclerosis. The aim of this study is to evaluate the relationship between aortic elastic properties and VT.
Elastic properties of aorta in patients with spontaneous VT, without history of known cardiovascular disease and cardiovascular risk factors (n: 31), and in healthy subjects without cardiovascular risk factors (n: 30) were compared. Elastic properties of the aorta were assessed with transthoracic echocardiography.
A significant increase in aortic stiffness index (6.5 ± 1.0 versus 6 ± 0.7, P = 0.03) and a significant decrease in aortic strain and aortic distensibility were found in patients with VT compared with healthy subjects (8.4 ± 7 versus 13 ± 8, P = 0.01, 4.9 ± 4.8 versus 6.5 ± 4.4, P = 0.03, respectively).
Elastic properties of aorta in patients with spontaneous VT were impaired. These results may support the role of endothelial dysfunction in the pathogenesis of VT.
近期研究中，静脉血栓形成（VT）与动脉粥样硬化之间的关系存在争议。主动脉弹性特性在检测动脉粥样硬化早期阶段具有预测价值。本研究旨在评估主动脉弹性特性与VT之间的关系。
比较了自发性VT患者（无已知心血管疾病和心血管危险因素病史，n = 31）和无心血管危险因素的健康受试者（n = 30）的主动脉弹性特性。通过经胸超声心动图评估主动脉弹性特性。
与健康受试者相比，VT患者的主动脉僵硬度指数显著增加（6.5±1.0对6±0.7，P = 0.03），主动脉应变和主动脉扩张性显著降低（分别为8.4±7对13±8，P = 0.01；4.9±4.8对6.5±4.4，P = 0.03）。
自发性VT患者的主动脉弹性特性受损。这些结果可能支持内皮功能障碍在VT发病机制中的作用。
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