Belen Erdal, Karaman Ozgur, Caliskan Gurkan, Atamaner Oya, Aslan Omer
Department of Cardiology, Okmeydanı Training and Research Hospital, Istanbul, Turkey.
Departments of Orthopedic and Traumatology, Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey
Vascular. 2016 Feb;24(1):70-7. doi: 10.1177/1708538115584728. Epub 2015 Apr 28.
Osteoarthritis is one of the most common chronic diseases and associated with increased cardiovascular comorbidity and deaths. Elastic properties of aorta are closely associated with cardiovascular mortality and morbidity. In our study, we aimed to evaluate aortic stiffness in primary osteoarthritis patients. A total of 160 patients including 80 patients with primary knee osteoarthritis and 80 controls without osteoarthritis were included in the study. Additionally, osteoarthritis patients were divided into four subgroups according to the severity of the disease. Aortic parameters were evaluated by using transthoracic echocardiography method. While measurements of aortic stiffness of osteoarthritis group were higher compared to the control group (p < 0.01), aortic strain and aortic distensibility measurements of osteoarthritis group are lower than the control group (p < 0.01). Additionally, it was determined that as the severity of osteoarthritis increased also aortic stiffness increased highly significantly (p = 0.001). Presence and severity of osteoarthritis are closely associated with elastic properties of aorta, which are correlated with cardiovascular mortality and morbidity.
骨关节炎是最常见的慢性疾病之一，与心血管合并症及死亡风险增加相关。主动脉的弹性特性与心血管疾病的死亡率和发病率密切相关。在我们的研究中，我们旨在评估原发性骨关节炎患者的主动脉僵硬度。该研究共纳入了160名患者，其中包括80名原发性膝骨关节炎患者和80名无骨关节炎的对照组。此外，骨关节炎患者根据疾病严重程度分为四个亚组。采用经胸超声心动图方法评估主动脉参数。骨关节炎组的主动脉僵硬度测量值高于对照组（p < 0.01），而骨关节炎组的主动脉应变和主动脉扩张性测量值低于对照组（p < 0.01）。此外，还确定随着骨关节炎严重程度的增加，主动脉僵硬度也显著增加（p = 0.001）。骨关节炎的存在和严重程度与主动脉的弹性特性密切相关，而主动脉弹性特性与心血管疾病的死亡率和发病率相关。
