Li Xuri, Kumar Anil, Zhang Fan, Lee Chunsik, Li Yang, Tang Zhongshu, Arjuna Pachiappan
National Eye Institute, NIH, Rockville, MD 20852, USA.
Oncotarget. 2010 Aug;1(4):309-314. doi: 10.18632/oncotarget.141.
VEGF is believed to be a master regulator in both developmental and pathological angiogenesis. The role of PDGF-C in angiogenesis, however, is only at the beginning of being revealed. We and others have shown that PDGF-C is a critical player in pathological angiogenesis because of its pleiotropic effects on multiple cellular targets. The angiogenic pathways induced by PDGF-C are, to a large extent, VEGF-independent. These pathways may include, but not limited to, the direct effect of PDGF-C on vascular cells, the effect of PDGF-C on tissue stroma fibroblasts, and its effect on macrophages. Taken together, the pleiotropic, versatile and VEGF-independent angiogenic nature of PDGF-C has placed it among the most important target genes for antiangiogenic therapy.
血管内皮生长因子（VEGF）被认为是发育性和病理性血管生成中的主要调节因子。然而，血小板衍生生长因子-C（PDGF-C）在血管生成中的作用才刚刚开始被揭示。我们和其他人已经表明，PDGF-C由于其对多个细胞靶点的多效性作用，是病理性血管生成中的关键参与者。PDGF-C诱导的血管生成途径在很大程度上不依赖于VEGF。这些途径可能包括但不限于PDGF-C对血管细胞的直接作用、PDGF-C对组织基质成纤维细胞的作用及其对巨噬细胞的作用。综上所述，PDGF-C的多效性、多功能性和不依赖VEGF的血管生成特性使其成为抗血管生成治疗最重要的靶基因之一。
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