齐多夫定诱导的可逆性纯红细胞再生障碍。
Zidovudine-induced reversible pure red cell aplasia.
机构信息
Departments of Medicine and Pathology, Kasturba Medical College, Manipal University, Manipal, Karnataka, India.
出版信息
Indian J Pharmacol. 2010 Jun;42(3):189-91. doi: 10.4103/0253-7613.66845.
Abstract
Hematological abnormalities are frequent among human immunodeficiency virus (HIV)-infected patients and may be directly attributable to the virus or may be caused by opportunistic infections, neoplasms or drugs that cause bone marrow suppression or hemolysis. Pure red cell aplasia (PRCA) is an uncommon hematological disorder that causes anemia. We report a 37-year-old male with HIV infection who developed PRCA 6 weeks after commencing Zidovudine and recovered following cessation of the drug. This is the first case of Zidovudine-induced PRCA reported from the Indian subcontinent.
摘要
血液学异常在人类免疫缺陷病毒（HIV）感染患者中很常见，可能直接归因于病毒，也可能由机会性感染、肿瘤或导致骨髓抑制或溶血的药物引起。纯红细胞再生障碍性贫血（PRCA）是一种罕见的血液系统疾病，可导致贫血。我们报告了一例 37 岁男性 HIV 感染者，在开始使用齐多夫定时出现 PRCA，停药后恢复。这是来自印度次大陆的首例齐多夫定诱导的 PRCA 病例。
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