奈韦拉平抑制 CD8+ 细胞的抗 HIV 活性。
Nevirapine inhibits the anti-HIV activity of CD8+ cells.
机构信息
Division of Hematology/Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143-1270, USA.
出版信息
J Acquir Immune Defic Syndr. 2013 Jun 1;63(2):184-8. doi: 10.1097/QAI.0b013e318289822d.
Antiretroviral therapy (ART) significantly reduced the CD8 cell noncytotoxic anti-HIV response in 12 HIV-1-infected subjects (P < 0.0001). In separate experiments, CD8(+) cells from long-term survivors were cocultured with HIV-infected CD4(+) cells using varying concentrations of anti-HIV drugs. The antiviral function of CD8(+) cells from 4 of the 14 LTSs was reduced with exposure to 10 μM of nevirapine (P < 0.05). The antiviral activity of CD8(+) cells from 2 LTSs was inhibited by 5 μM of zidovudine. These studies indicate that nevirapine and probably zidovudine can inhibit the anti-HIV activity of CD8(+) cells and thus could influence the effectiveness of antiretroviral therapy.
抗逆转录病毒疗法（ART）显著降低了 12 名 HIV-1 感染者的 CD8 细胞非细胞毒性抗 HIV 反应（P < 0.0001）。在单独的实验中，用不同浓度的抗 HIV 药物将长期存活者的 CD8(+)细胞与 HIV 感染的 CD4(+)细胞共培养。在 14 名 LTS 中的 4 名中，暴露于 10 μM 的奈韦拉平可降低 CD8(+)细胞的抗病毒功能（P < 0.05）。2 名 LTS 的 CD8(+)细胞的抗病毒活性被 5 μM 的齐多夫定抑制。这些研究表明，奈韦拉平，可能还有齐多夫定，能够抑制 CD8(+)细胞的抗 HIV 活性，从而可能影响抗逆转录病毒治疗的效果。
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