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马来西亚东部卡达山杜顺人中α和β地中海贫血的高患病率:为一个原住民群体提供有效医疗保健面临的挑战。

High prevalence of alpha- and beta-thalassemia in the Kadazandusuns in East Malaysia: challenges in providing effective health care for an indigenous group.

作者信息

Tan Jin-Ai Mary Anne, Lee Ping-Chin, Wee Yong-Chui, Tan Kim-Lian, Mahali Noor Fadzlin, George Elizabeth, Chua Kek-Heng

机构信息

Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.

出版信息

J Biomed Biotechnol. 2010;2010. doi: 10.1155/2010/706872. Epub 2010 Sep 5.

Abstract

Thalassemia can lead to severe transfusion-dependent anemia, and it is the most common genetic disorder in Malaysia. This paper aims to determine the prevalence of thalassemia in the Kadazandusuns, the largest indigenous group in Sabah, East Malaysia. α- and β-thalassemia were confirmed in 33.6% and 12.8%, of the individuals studied respectively. The high prevalence of α- and β-thalassemia in the Kadazandusuns indicates that thalassemia screening, genetic counseling, and prenatal diagnosis should be included as part of their healthcare system. This preliminary paper serves as a baseline for further investigations into the health and genetic defects of the major indigenous population in Sabah, East Malaysia.

摘要

地中海贫血可导致严重的依赖输血的贫血症,它是马来西亚最常见的遗传性疾病。本文旨在确定东马来西亚沙巴最大的原住民群体卡达山杜顺人中地中海贫血的患病率。在所研究的个体中,分别有33.6%和12.8%的人被确诊患有α型和β型地中海贫血。卡达山杜顺人中α型和β型地中海贫血的高患病率表明,地中海贫血筛查、遗传咨询和产前诊断应纳入他们的医疗保健系统。这篇初步报告为进一步调查东马来西亚沙巴主要原住民群体的健康状况和遗传缺陷提供了基线。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f194/2943116/f8721cddc7c8/JBB2010-706872.001.jpg

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