Hauner H, Schubert J, Pfeiffer E F
Abteilung Innere Medizin I, Universität Ulm.
Med Klin (Munich). 1990 Dec 15;85(12):690-5.
In a retrospective study, we analyzed the prevalence of diabetes-associated late complications in 549 type 1 (insulin-dependent) diabetic patients who have been treated at the University Hospital of Ulm between 1980 and 1987. Retinopathy, proteinuria and neuropathy depended on the duration of the disease, whereas age was the major determinant of large vessel disease. After 20 years of diabetes, 85% of the patients showed retinopathy, half of them proliferative retinopathy, 52% had persistent proteinuria (greater than 500 mg/day), 20% of them were under dialysis. 74% of the patients showed signs of peripheral and/or autonomic neuropathy, 19% had manifestations of large vessel disease. There was no consistent correlation between the levels of glycosylated hemoglobin and the occurrence of diabetic late complications. However, hypertension was closely associated with both small and large vessel disease.
在一项回顾性研究中，我们分析了1980年至1987年间在乌尔姆大学医院接受治疗的549例1型（胰岛素依赖型）糖尿病患者中糖尿病相关晚期并发症的患病率。视网膜病变、蛋白尿和神经病变取决于病程，而年龄是大血管疾病的主要决定因素。糖尿病20年后，85%的患者出现视网膜病变，其中一半为增殖性视网膜病变，52%有持续性蛋白尿（每日超过500毫克），20%的患者接受透析治疗。74%的患者有周围和/或自主神经病变的体征，19%有大血管疾病的表现。糖化血红蛋白水平与糖尿病晚期并发症的发生之间没有一致的相关性。然而，高血压与小血管和大血管疾病均密切相关。
