Norymberg C, Shenkman L
Diabetic Unit, Netanya, Israel.
Isr J Med Sci. 1991 Mar;27(3):124-30.
We performed a retrospective study on 1,019 patients with noninsulin-dependent diabetes who were followed for the past 20 years in our Diabetic Unit in order to determine the prevalence of overt diabetic nephropathy in relation to the other known complications of diabetes. In comparison with neuropathy, retinopathy and peripheral vascular disease, whose prevalence was 23.4%, 28.0%, and 27.4% respectively, the prevalence of macroproteinuria was significantly lower (7.0%). The prevalence of complications was correlated directly with patient age and duration of diabetes, and inversely with the degree of metabolic control. The reasons for the low prevalence of overt diabetic nephropathy in our population of noninsulin-dependent diabetics may be related to genetic factors, diet, other unknown environmental factors, or higher mortality rates in patients with renal disease.
我们对1019例非胰岛素依赖型糖尿病患者进行了一项回顾性研究，这些患者在我们糖尿病科接受了为期20年的随访，以确定显性糖尿病肾病相对于糖尿病其他已知并发症的患病率。与神经病变、视网膜病变和周围血管疾病的患病率分别为23.4%、28.0%和27.4%相比，大量蛋白尿的患病率显著较低（7.0%）。并发症的患病率与患者年龄和糖尿病病程直接相关，与代谢控制程度呈负相关。在我们的非胰岛素依赖型糖尿病患者人群中，显性糖尿病肾病患病率较低的原因可能与遗传因素、饮食、其他未知环境因素或肾病患者较高的死亡率有关。
