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[空肠黏膜萎缩患儿维生素E的肠道吸收情况]

[Intestinal absorption of vitamin E in children with atrophy of the jejunal mucosa].

作者信息

Lubrano R, Lucidi V, Belli A, Cardilli V, Mannarino O, Panseri C, Strappini P M, Castro M, Giardini O

机构信息

Istituto di Clinica Pediatrica, Universita degli Studi di Roma La Sapienza, Roma.

出版信息

Minerva Pediatr. 1990 Dec;42(12):537-9.

PMID:2087227
Abstract

The intestinal absorption of vitamin E is often thought to be closely correlated to that of fatty acids, but the biochemical mechanisms involved in the process are still not clear. For this reason, the present study aimed to assess the absorption of triglycerides and vitamin E, following oral administration, in 11 children with suspected malabsorption syndromes. Intestinal biopsy in 9 children showed the presence of a flat mucosa, whereas no changes were present in 2 patients. The results confirm the inverse correlation between the absorption of triglycerides and vitamin E, as if tocopherols used an independent system of transport. These findings contrast with those reported in the literature perhaps due to the low level of precision of colorimetric techniques previously used to assay vitamin E.

摘要

维生素E的肠道吸收通常被认为与脂肪酸的吸收密切相关,但该过程涉及的生化机制仍不清楚。因此,本研究旨在评估11名疑似吸收不良综合征儿童口服后甘油三酯和维生素E的吸收情况。9名儿童的肠道活检显示存在扁平黏膜,而2名患者未出现变化。结果证实了甘油三酯吸收与维生素E吸收之间的负相关,就好像生育酚使用了一个独立的转运系统。这些发现与文献报道的结果相反,这可能是由于先前用于测定维生素E的比色技术精度较低。

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