[The levels of endothelin, neuron-specific enolase, and their autoantibodies in the serum and tear fluid of patients with type 2 diabetes mellitus].

Enzyme immunoassay was used to measure the serum and tear fluid concentrations of endothelin, neuron-specific enolase (NSE), and their autoantibodies in 19 patients with nonproliferative diabetic retinopathy (NDR). The serum and tear fluid levels of endothelin were shown to increase in patients with NDR. At the same time, the content of endothelin-1 autoantibodies rose in the blood and remained in the normal range in the tear fluid. The concentration of NSE showed an 18-fold increase in the tear fluid and the content of its autoantibodies remained unchanged.