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[连续电场对实验性角膜愈合的影响]

[Impact of a continuous electric field on corneal healing in an experiment].

作者信息

Zheleznov E A, Fedorov A A, Sheludchenko V M

出版信息

Vestn Oftalmol. 2010 Jul-Aug;126(4):30-5.

PMID:20873155
Abstract

The impact of a continuous electric field on reepithelization of the standardized erosive wound surface of the cornea was studied in 54 rabbits. Erosions were treated with antibacterial drugs, reparants (a control) and simultaneously with exposure to a 500 mV/mm2 electric field acting until complete epithelization was achieved (an experiment). Dynamics in the process was recorded by photography after fluorescein staining. Twenty corneal samples were histologically studied 1, 2, 3 days and 3-4 weeks after injury. It has been shown that the use of a continuous electric field does not prevent and, in most cases, it accelerates corneal erosion epithelization. The method may be used as a factor of erosion healing stimulation. It is most expedient to apply the method within the first 2 days before epithelial defect closure.

摘要

在54只兔子身上研究了连续电场对标准化角膜糜烂创面再上皮化的影响。糜烂创面分别用抗菌药物、修复剂(作为对照)治疗,同时暴露于500 mV/mm2的电场中,直至完全上皮化(实验)。用荧光素染色后通过摄影记录该过程的动态变化。在损伤后1、2、3天以及3 - 4周对20个角膜样本进行组织学研究。结果表明,使用连续电场不会阻碍,且在大多数情况下会加速角膜糜烂的上皮化。该方法可作为刺激糜烂愈合的一个因素。在上皮缺损闭合前的前两天内应用该方法最为适宜。

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