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[癫痫患者的精神障碍与大脑感觉运动不对称性]

[Mental disorders and cerebral sensomotor asymmetry in patients with epilepsy].

作者信息

Zemlianaia A A, Kalinin V V, Koviazina M S, Krylov O E

出版信息

Zh Nevrol Psikhiatr Im S S Korsakova. 2010;110(3 Suppl 2):75-81.

Abstract

A neurological, psychiatric and instrumental (electroencephalography, computer tomography, etc.) study of 84 patients was aimed at assessing an effect of sensomotor asymmetry profile and side of the epileptic focus on semiotics of seizures and psychopathological presentations in partial epilepsy. A data analysis included 111 variables, i.e., psychometric and neuropsychological ones. Groups of patients with left and right profiles of functional interhemispheric asymmetry (LHA and RHA) were singled out. No between-group differences were found in severity of mental disturbances. However, cognitive functions were mostly affected in RHA and psychopathological phenomenon emerged mostly in LPA. The formation of multiple epileptic foci with the involvement of frontal and temporary lobes was the best predictor of mental disorders manifestation compared to age at disease onset, illness duration, frequency and severity of seizures.

摘要

对84例患者进行了神经学、精神病学及仪器检查(脑电图、计算机断层扫描等),旨在评估感觉运动不对称特征及癫痫病灶侧别对部分性癫痫发作的症状学及精神病理学表现的影响。数据分析包括111个变量,即心理测量学和神经心理学变量。区分出了具有左、右功能性半球间不对称特征(LHA和RHA)的患者组。在精神障碍严重程度方面未发现组间差异。然而,认知功能在RHA中受影响最大,而精神病理现象大多出现在LPA中。与发病年龄、病程、发作频率和严重程度相比,额叶和颞叶受累形成多个癫痫病灶是精神障碍表现的最佳预测指标。

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