姜黄素聚氰基丙烯酸正丁酯纳米粒的制备与表征
[Preparation and characterization of curcumin polybutylcyanoacrylate nanoparticles].
作者信息
Zhu Xiu-qing, Sun Min, Zhu Fan-ping, Ding Ting-ting, Zhai Ying-jie, Zhai Guang-xi
机构信息
College of Pharmacy, Shandong University, Jinan 250012, China.
出版信息
Zhong Yao Cai. 2010 May;33(5):797-801.
OBJECTIVE
To prepare curcumin polybutylcyanoacrylate nanoparticles (Cur-PBCNs) and evaluate its characteristics.
METHODS
Cur-PBCNs were prepared by emulsion polymerization, and the formulation was optimized by L16 (4(3)) orthogonal design test with entrapment efficiency and drug loading as indices. In addition, its characteristics were investigated.
RESULTS
The nanoparticles were spherical in appearance under transmission electron microscope (TEM). The mean diameter of the nanoparticles was 93.8 nm, the mean entrapment efficiency was (50.4 +/- 2.2)%, the mean drug-loading was (33.5 +/- 0.9)% and the Zeta potential was -6.81 mV. The total drug release was 34.74% in 2 hours followed by a sustained release in vitro for Cur-PBCNs, and the in vitro release profile of the nanoparticles was fit for two phases kinetics equation: 100 - Q = 4.5235e(-0.1724t) + 4.1641e(-0.0114t).
CONCLUSION
The optimal Cur-PBCNs show good characteristics and sustained release character in vitro.
目的
制备姜黄素聚氰基丙烯酸正丁酯纳米粒（Cur-PBCNs）并评价其特性。
方法
采用乳液聚合法制备Cur-PBCNs，以包封率和载药量为指标，通过L16(4(3))正交设计试验优化处方。此外，对其特性进行了研究。
结果
透射电子显微镜（TEM）下纳米粒呈球形。纳米粒平均粒径为93.8nm，平均包封率为(50.4±2.2)%，平均载药量为(33.5±0.9)%，Zeta电位为-6.81mV。Cur-PBCNs在2小时内总药物释放率为34.74%，随后在体外呈缓释，纳米粒的体外释放曲线符合双相动力学方程：100 - Q = 4.5235e(-0.1724t) + 4.1641e(-0.0114t)。
结论
优化后的Cur-PBCNs具有良好的特性和体外缓释特性。
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