Gera Meeta, Sharma Neelesh, Ghosh Mrinmoy, Huynh Do Luong, Lee Sung Jin, Min Taesun, Kwon Taeho, Jeong Dong Kee
Department of Animal Biotechnology, Faculty of Biotechnology, Jeju National University, Jeju, Republic of Korea.
Division of Veterinary Medicine, Faculty of Veterinary Science and Animal Husbandry, Sher-e-Kashmi University of Agricultural Sciences and Technology, R.S. Pura, Jammu, India.
Oncotarget. 2017 Jul 11;8(39):66680-66698. doi: 10.18632/oncotarget.19164. eCollection 2017 Sep 12.
Curcumin is a natural polyphenol and essential curcuminoid derived from the rhizome of the medicinal plant (.) is universally acknowledged as "". It is a vital consumable and restorative herb, commonly keened for several ailments such as cancer, arthritis, pain, bruises, gastrointestinal quandaries, swelling and much more. Despite its enormous curative potential, the poor aqueous solubility and consequently, minimal systemic bioavailability with rapid degradation are some of the major factors which restrict the utilization of curcumin at medical perspective. However, to improve its clinically relevant parameters, nanoformulation of curcumin is emerging as a novel substitute for their superior therapeutic modality. It enhances its aqueous solubility and targeted delivery to the tissue of interest that prompts to enhance the bioavailability, better drug conveyance, and more expeditious treatment. Subsequent investigations are endeavored to enhance the bio-distribution of native curcumin by modifying with felicitous nano-carriers for encapsulation. In this review, we specifically focus on the recent nanotechnology based implementations applied for overcoming the innate constraints of native curcumin and additionally the associated challenges which restrict its potential therapeutic applications both and studies, as well as their detailed mechanism of action, have additionally been discussed.
姜黄素是一种天然多酚和源自药用植物根茎的主要姜黄素类化合物，被公认为“ ”。它是一种重要的可食用和药用草本植物，常用于治疗多种疾病，如癌症、关节炎、疼痛、瘀伤、胃肠道问题、肿胀等等。尽管姜黄素具有巨大的治疗潜力，但水溶性差，进而导致全身生物利用度极低且迅速降解，这些是从医学角度限制姜黄素应用的一些主要因素。然而，为了改善其临床相关参数，姜黄素的纳米制剂正作为一种具有卓越治疗方式的新型替代品而出现。它提高了姜黄素的水溶性，并将其靶向递送至目标组织，从而提高生物利用度、改善药物传递并实现更快速的治疗。后续研究致力于通过用合适的纳米载体进行修饰以增强天然姜黄素的生物分布用于包封。在本综述中，我们特别关注基于纳米技术的最新应用，这些应用用于克服天然姜黄素固有的局限性，此外还讨论了限制其在体内和体外研究中潜在治疗应用的相关挑战，以及它们详细的作用机制。
