Gemma K, Tajima H, Ito K, Murakami R, Kumazaki T, Ebata K, Akama Y
Department of Radiology, Nippon Medical School.
Nihon Igaku Hoshasen Gakkai Zasshi. 1990 Nov 25;50(11):1436-8.
Abdominal angiography using ioxaglate (3.0-4.5 ml/kg) was performed in 10 patients with normal renal function. Ccr, FENa, CH2O were compared before and immediately after angiography. There was no significant change in Ccr and CH2O level, while FENa increased remarkably after angiography. This study suggested that the osmotic diuresis and the proximal tubular stress were induced by administrated low osmolality contrast material during conventional abdominal angiography.
对10例肾功能正常的患者进行了使用碘克沙醇(3.0 - 4.5 ml/kg)的腹部血管造影。比较了血管造影前及造影后即刻的内生肌酐清除率(Ccr)、滤过钠排泄分数(FENa)、自由水清除率(CH2O)。Ccr和CH2O水平无显著变化,而血管造影后FENa显著升高。本研究提示,在传统腹部血管造影过程中,低渗性造影剂的给药可诱发渗透性利尿和近端肾小管应激。