Ferchmin P A, Eterović V A
Department of Biochemistry School of Medicine, Universidad Central del Caribe, Bayamon, Puerto Rico.
Pharmacol Biochem Behav. 1990 Nov;37(3):445-9. doi: 10.1016/0091-3057(90)90010-f.
The effect of putrescine and cyclohexylamine on rat cortical polyamine concentration and on behavior in a black and white maze was studied. The levels of polyamines in brain cortex were determined 15 min, 2, 4, and 6 hours after injection of putrescine (200 or 400 mg/kg) or cyclohexylamine (380 mg/kg). Putrescine concentration increased 6-fold 15 min after injection of putrescine followed by a decline during the next 6 hours. Cyclohexylamine increased putrescine concentration doubling it 4 hours after injection. Spermidine and spermine concentrations did not change after either putrescine or cyclohexylamine injection. Behavior was studied in the Greek cross maze which provides the choice to enter either white or black compartments. Putrescine 200 mg/kg decreased entries into white but not black compartments, while putrescine 400 mg/kg decreased entries into both. The effect of cyclohexylamine was similar to putrescine 400 mg/kg. The behavioral effect of each treatment was independent of the time between injection and testing for up to 6 hours, while the levels of putrescine changed during the same period. Therefore, behavior was not directly related to total cortical putrescine.
研究了腐胺和环己胺对大鼠皮质多胺浓度以及黑白迷宫中行为的影响。在注射腐胺（200或400mg/kg）或环己胺（380mg/kg）后的15分钟、2小时、4小时和6小时，测定大脑皮质中的多胺水平。注射腐胺后15分钟，腐胺浓度增加了6倍，随后在接下来的6小时内下降。环己胺使腐胺浓度在注射后4小时增加了一倍。注射腐胺或环己胺后，亚精胺和精胺浓度均未改变。在希腊十字迷宫中研究行为，该迷宫提供进入白色或黑色隔室的选择。200mg/kg的腐胺减少了进入白色隔室的次数，但不影响进入黑色隔室的次数，而400mg/kg的腐胺减少了进入两个隔室的次数。环己胺的作用与400mg/kg的腐胺相似。每种处理的行为效应在注射和测试之间长达6小时内与时间无关，而腐胺水平在同一时期发生变化。因此，行为与皮质总腐胺没有直接关系。
