Kawakami Yoshio, Nakamura-Wakatsuki Taeko, Yamamoto Toshiyuki
Dermatol Online J. 2010 Sep 15;16(9):12.
We describe a 72-year-old man suffering from renal cell carcinoma with lung metastases who developed scaly erythema on his face after the administration of recombinant interleukin-2 (rIL-2). A skin biopsy revealed intraepidermal and superficial perivascular infiltrate of mononuclear cells that were mainly composed of CD3 positive T-cells. There have been two cases of seborrheic dermatitis-like eruption induced by rIL-2. However, neither of them had histopathological evaluation. To our knowledge, this is the first case of seborrheic dermatitis-like eruption following rIL-2 administration whose histopathological investigations were performed.
我们描述了一名72岁患有肾细胞癌伴肺转移的男性患者，其在接受重组白细胞介素-2（rIL-2）治疗后面部出现鳞屑性红斑。皮肤活检显示表皮内和浅表血管周围有单核细胞浸润，主要由CD3阳性T细胞组成。已有两例由rIL-2引起的脂溢性皮炎样皮疹病例。然而，这两例均未进行组织病理学评估。据我们所知，这是首例接受rIL-2治疗后出现脂溢性皮炎样皮疹并进行了组织病理学检查的病例。
