Departments of Medicine and Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wis, USA.
Transl Res. 2010 Oct;156(4):216-25. doi: 10.1016/j.trsl.2010.07.004. Epub 2010 Aug 13.
Hemodialysis vascular access is a unique form of vascular anastomosis. Although it is created in a unique disease state, it has much to offer in terms of insights into venous endothelial and anastomotic biology. The development of neointimal hyperplasia (NH) has been identified as a pathologic entity, decreasing the lifespan and effectiveness of hemodialysis vascular access. Subtle hints and new data suggest a contrary idea-that NH, to some extent an expected response, if controlled properly, may play a beneficial role in the promotion of maturation to a functional access. This review attempts to recast our understanding of NH and redefine research goals for an evolving discipline that focuses on a life-sustaining connection between an artery and vein.
血液透析血管通路是一种独特的血管吻合形式。尽管它是在一种独特的疾病状态下创建的，但它在静脉内皮和吻合生物学方面提供了很多见解。新生内膜增生（NH）的发展已被确定为一种病理实体，降低了血液透析血管通路的寿命和有效性。微妙的暗示和新数据表明了一个相反的观点——如果得到适当控制，NH 在某种程度上是一种预期的反应，可能会在促进成熟为功能性通路方面发挥有益作用。本综述试图重新构建我们对 NH 的理解，并为一个专注于动脉和静脉之间维持生命连接的不断发展的学科重新定义研究目标。
