Teller M N, Giner-Sorolla A, Stöhrer G, Budinger J M, Brown G B
Cancer Res. 1978 Aug;38(8):2229-32.
Injection s.c. of purine 3-oxide into Wistar rats resulted in the appearance of sarcomas and fibromas at the interscapular site of administration, carcinomas in the liver, and a high incidence of s.c. fibromas in the hip at a distance from the site of injection. A small number of liver tumors but not tumors at the injection site appeared in rats to which the parent compound, purine, was administered. Oxidation of purine 3-oxide by xanthine oxidase was found to occur in two steps to yield the potent oncogen 3-hydroxyxanthine. A similar process may occur in vivo since a protein preparation from rat s.c. tissue has similar oxidizing activity.
向Wistar大鼠皮下注射嘌呤3 - 氧化物，导致给药的肩胛间部位出现肉瘤和纤维瘤、肝脏出现癌，且在距注射部位一定距离的臀部皮下纤维瘤发生率很高。给大鼠施用母体化合物嘌呤后，出现了少量肝脏肿瘤，但注射部位未出现肿瘤。发现黄嘌呤氧化酶将嘌呤3 - 氧化物氧化分两步进行，生成强效致癌原3 - 羟基黄嘌呤。由于大鼠皮下组织的蛋白质制剂具有类似的氧化活性，因此体内可能发生类似过程。
