表达具有6A和6B两种血清型表位的荚膜的肺炎链球菌分离株。
Streptococcus pneumoniae isolates expressing a capsule with epitopes of both serotypes 6A and 6B.
作者信息
Sheppard Carmen L, Pichon Bruno, George Robert C, Hall Lucinda M C
机构信息
Respiratory and Systemic Infection Laboratory, Health Protection Agency Centre for Infections, 61 Colindale Avenue, London NW9 5EQ, United Kingdom.
出版信息
Clin Vaccine Immunol. 2010 Nov;17(11):1820-2. doi: 10.1128/CVI.00335-10. Epub 2010 Sep 28.
Abstract
Four Streptococcus pneumoniae isolates expressing both 6A and 6B capsular serotypes were detected by a multiplex immunoassay. The sequence of WciP, a GT2-family glycosyltransferase, indicates that point mutation has compromised linkage specificity, allowing two alternative oligosaccharides to be synthesized. This finding highlights that mutation as well as recombination can mediate serotype change.
摘要
通过多重免疫测定法检测到4株同时表达6A和6B荚膜血清型的肺炎链球菌分离株。GT2家族糖基转移酶WciP的序列表明，点突变损害了连接特异性，从而允许合成两种不同的寡糖。这一发现突出表明，突变以及重组均可介导血清型变化。
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