Khatuntseva Elena A, Kamneva Anastasia A, Yashunsky Dmitry V, Nifantiev Nikolay E
N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow 119991, Russia.
Molecules. 2025 Jul 22;30(15):3068. doi: 10.3390/molecules30153068.
This review focuses on the synthesis of spacer-armed phosphooligosaccharides structurally related to the capsular phosphoglycans of pathogenic bacteria, including the serotypes a, b, c, and f, serogroups a and x, the serotypes 6a, 6b, 6c, 6f, 19a, and 19f, and the serotype HS:53, strain RM1221, in which the phosphodiester linkage is a structural component of a phosphoglycan backbone. Also, in this review, we summarize the current knowledge on the preparation and immunogenicity of neoglycoconjugates based on synthetic phosphooligosaccharides. The discussed data helps evaluate the prospects for the development of conjugate vaccines on the basis of synthetic phosphooligosaccharide antigens.
本综述聚焦于与致病细菌荚膜磷酸聚糖结构相关的间隔臂磷酸寡糖的合成，这些致病细菌包括血清型a、b、c和f，血清群a和x，血清型6a、6b、6c、6f、19a和19f，以及血清型HS:53、菌株RM1221，其中磷酸二酯键是磷酸聚糖主链的结构组成部分。此外，在本综述中，我们总结了基于合成磷酸寡糖的新糖缀合物的制备和免疫原性的现有知识。所讨论的数据有助于评估基于合成磷酸寡糖抗原的结合疫苗的开发前景。
