来自铜头蝮蛇毒液的一种纤维蛋白促进酶对大鼠纤维蛋白原和血浆的作用。

The action of a fibrin-promoting enzyme from the venom of Agkistrodon contortrix contortrix on rat fibrinogen and plasma.

作者信息

Dyr J E, Suttnar J, Simák J, Fortová H, Kornalík F

机构信息

Institute of Hematology and Blood Transfusion, Prague, Czechoslovakia.

出版信息

Toxicon. 1990;28(11):1364-7. doi: 10.1016/0041-0101(90)90103-e.

DOI:10.1016/0041-0101(90)90103-e

PMID:2087698

Abstract

The action of a fibrin-promoting enzyme isolated from the venom of A.c.contortrix was investigated. The ratio of fibrinopeptides A and B released was similar in isolated human and rat fibrinogen and human plasma, fibrinopeptide B always being released preferentially. However, no clotting occurred in rat plasma, and no fibrinopeptides were released even after prolonged incubation. The results suggest strong, fast-acting irreversible neutralization of the enzyme activity in rat plasma.

摘要

对从扭曲蝮蛇毒液中分离出的一种促进纤维蛋白形成的酶的作用进行了研究。在分离出的人及大鼠纤维蛋白原和人血浆中，释放的纤维蛋白肽A和B的比例相似，纤维蛋白肽B总是优先释放。然而，大鼠血浆中未发生凝血，即使长时间孵育后也未释放纤维蛋白肽。结果表明大鼠血浆中该酶的活性被强烈、快速起作用的不可逆中和。