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前列腺特异性抗原——有用的筛查工具还是潜在的负担?

Prostate specific antigen - useful screening tool or potential liability?

作者信息

Mahar Patrick, Sengupta Shomik, Ludlow Karinne, Corcoran Niall

机构信息

Urology Unit, The Alfred, Melbourne, Victoria.

出版信息

Aust Fam Physician. 2010 Aug;39(8):598-600.

PMID:20877758
Abstract

BACKGROUND

The uncertainty regarding prostate specific antigen (PSA) screening for prostate cancer has not been alleviated, despite recent randomised controlled trials and position statements released by authoritative bodies.

OBJECTIVE

This article summarises authoritative position statements by representative bodies in Australia and describes legal considerations for a general practitioner when deciding whether to order PSA tests as a screening tool for prostate cancer.

DISCUSSION

Prostate specific antigen as a primary screening tool is generally not endorsed by most authoritative bodies in Australia, with the exception in some circumstances for men 55-69 years of age. Where asymptomatic patients request a PSA be undertaken, a GP can be justified both to order a PSA test or not to, such is the context of peer professional opinion provisions in Australian legislation and conflicting authoritative position statements regarding PSA.Where there is still ongoing uncertainty, the matter may be appropriately referred for specialist consideration.

摘要

背景

尽管最近有随机对照试验以及权威机构发布的立场声明,但前列腺癌前列腺特异性抗原(PSA)筛查的不确定性仍未得到缓解。

目的

本文总结了澳大利亚代表性机构的权威立场声明,并描述了全科医生在决定是否将PSA检测作为前列腺癌筛查工具时的法律考量。

讨论

在澳大利亚,大多数权威机构通常不认可将前列腺特异性抗原作为主要筛查工具,55至69岁男性在某些情况下除外。对于无症状患者要求进行PSA检测的情况,全科医生决定是否进行PSA检测均合理,这是澳大利亚立法中同行专业意见条款以及关于PSA的相互矛盾的权威立场声明所导致的。在不确定性仍然存在的情况下,该问题可适当提交给专科医生考虑。

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Prostate specific antigen - useful screening tool or potential liability?前列腺特异性抗原——有用的筛查工具还是潜在的负担?
Aust Fam Physician. 2010 Aug;39(8):598-600.
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[Clinical value of prostate specific antigen screening in early detection of prostate cancer].前列腺特异性抗原筛查在前列腺癌早期检测中的临床价值
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The effect of obesity and lower serum prostate-specific antigen levels on prostate-cancer screening results in American men.肥胖与较低血清前列腺特异性抗原水平对美国男性前列腺癌筛查结果的影响。
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Prostate-specific antigen testing and prostate cancer screening.前列腺特异性抗原检测与前列腺癌筛查。
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Critical appraisal of prostate-specific antigen in prostate cancer screening: 20 years later.前列腺癌筛查中前列腺特异性抗原的批判性评估:20年后
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Depression and prostate cancer: implications for urologists and oncologists.抑郁与前列腺癌:泌尿科医生和肿瘤学家的相关考虑。
Nat Rev Urol. 2020 Oct;17(10):571-585. doi: 10.1038/s41585-020-0354-4. Epub 2020 Jul 30.