Department of Molecular Biology, Faculty of Science, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands.
Int J Oncol. 2010 Nov;37(5):1061-70. doi: 10.3892/ijo_00000757.
The p53 protein is a tumor suppressor that plays a crucial role in cellular growth regulation inducing a plethora of response pathways. p53 post-translational modifications, p53-binding proteins, co-factors and the p53-family members p63 and p73 have all been described to contribute to p53 target gene regulation and hence cellular outcome. However, the molecular mechanisms that discriminate between the different p53-responses towards stress treatments have remained largely elusive. This review focuses on the topic of the molecular mechanisms behind target gene selectivity of the transcription factor p53 and provides insight into the latest era of p53 research.
p53 蛋白是一种肿瘤抑制因子，在细胞生长调控中起着至关重要的作用，可诱导多种反应途径。p53 的翻译后修饰、p53 结合蛋白、共因子以及 p53 家族成员 p63 和 p73 都被描述为有助于 p53 靶基因的调控，从而影响细胞的命运。然而，区分应激处理中不同 p53 反应的分子机制在很大程度上仍未被揭示。本综述聚焦于转录因子 p53 靶基因选择性的分子机制这一主题，并深入探讨了 p53 研究的最新时代。
