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多发性骨纤维结构不良伴巨人症和巨大骨盆肿瘤:McCune-Albright 综合征的罕见病例。

Polyostotic fibrous dysplasia with gigantism and huge pelvic tumor: a rare case of McCune-Albright syndrome.

机构信息

Department of Bone and Joint Surgery, Ehime University Graduate School of Medicine, Shitsukawa, Toon, Ehime 791-0204, Japan.

出版信息

Int J Clin Oncol. 2011 Jun;16(3):270-4. doi: 10.1007/s10147-010-0127-9. Epub 2010 Sep 29.

Abstract

We report a rare case of polyostotic fibrous dysplasia on endocrine hyperfunction with elevated human growth hormone and normal serum level of prolactin. There were some differential points of gender, gigantism, endocrine function, and GNAS gene from McCune-Albright syndrome. Malignant transformation was suspected in the pelvic tumor from imaging because rapid growth of the tumor by imaging was observed; however, no malignant change occurred in this case.

摘要

我们报告了一例罕见的多骨性纤维结构不良伴内分泌功能亢进,表现为人增长激素升高而催乳素血清水平正常。该病与 McCune-Albright 综合征在性别、巨人症、内分泌功能和 GNAS 基因等方面存在一些不同点。由于影像学检查发现肿瘤快速生长,怀疑盆腔肿瘤发生恶性转化;然而,本例并未发生恶性变化。

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