Department of Chemistry, Graduate School of Science, Kyoto University, Kyoto 606-8502, Japan.
Chem Rec. 2010 Oct;10(5):254-9. doi: 10.1002/tcr.201000019.
A series of chiral quaternary ammonium salts derived from commercially available (R)- or (S)-binaphthol have been designed as new C(2)-symmetric chiral phase transfer catalysts. In order to realize the flexible design of these phase transfer catalysts, the combinatorial design approach has been developed. These chiral high-performance organocatalysts have been successfully applied to the highly practical asymmetric synthesis of various amino acid derivatives including α-alkyl and α,α-dialkyl-α-amino acids in addition to alkaloids.
一系列手性季铵盐衍生自商业可得的（R）-或（S）-联萘酚，被设计为新型 C(2)-对称手性相转移催化剂。为了实现这些相转移催化剂的灵活设计，开发了组合设计方法。这些手性的高性能有机催化剂已成功应用于各种氨基酸衍生物，包括α-烷基和α，α-二烷基-α-氨基酸，以及生物碱的高度实用的不对称合成。
