Schmolke B
Immunologischen Laboratorien, Berlin.
Z Lymphol. 1990 Dec;14(2):58-61.
Tumour markers are substances stemming either from the tumour cell itself or the production of which is stimulated by the malignant growth. They are released into body fluids where they can be detected quantitatively with the aid of sensitive immunological methods. In addition to oncofetal antigens they include hormones, enzymes, isoenzymes as well as special proteins. The determination of markers by aid of monoclonal antibodies has led to an additional improvement in tumour diagnostics. Tumour markers are indubitably valuable preoperatively as prognostic parameters, and postoperatively for the follow-up and after-care. However, the tumour-associated substances so far in use are unsuitable for the early recognition of malignant processes.
肿瘤标志物是源于肿瘤细胞本身的物质,或者其产生受到恶性生长的刺激。它们释放到体液中,借助灵敏的免疫方法可对其进行定量检测。除癌胚抗原外,它们还包括激素、酶、同工酶以及特殊蛋白质。借助单克隆抗体测定标志物已使肿瘤诊断有了进一步的改进。肿瘤标志物无疑是术前作为预后参数以及术后用于随访和后续护理的宝贵指标。然而,目前所使用的肿瘤相关物质并不适用于恶性病变的早期识别。