Department of Respiratory Medicine, West China Hospital of Sichuan University, Guoxuexiang 37, Chengdu, Sichuan, China.
Allergy. 2011 Feb;66(2):197-205. doi: 10.1111/j.1398-9995.2010.02438.x. Epub 2010 Sep 29.
The insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene has been implicated in susceptibility to asthma, but a large number of studies have reported inconclusive results. The aim of this study is to investigate the association between the I/D polymorphism of ACE gene and asthma risk by meta-analysis.
We searched Medline (Ovid), Pubmed, CNKI, Wanfang, and Weipu database, covering all papers until March 12, 2010. Statistical analysis was performed by using the software revman 4.2 (The Cochrane Collaboration, http://www.cochrane.org) and stata 10.0 (StataCorp, College Station, TX, USA, http://www.stata.com).
A total of 1946 cases and 2152 controls in 18 case-control studies were included in this meta-analysis. The results indicated that the DD homozygote carriers had a 59% increased risk of asthma, when compared with the homozygotes II and heterozygote DI [odds ratio (OR)=1.59, 95% confidence interval (CI): 1.16-2.18]. In the subgroup analysis by ethnicity, significant elevated risks were associated with DD homozygote carriers in Asians (OR=2.02 and 95% CI: 1.29-3.16 for DD vs DI+II) but not in Caucasians (OR=1.14 and 95% CI: 0.76-1.72 for DD vs DI+II). In the subgroup analysis by age, significant elevated risks were associated with DD homozygote carriers in children (OR=2.44 and 95% CI: 1.36-4.38 for DD vs II+DI) but not in adults (OR=1.54 and 95% CI: 0.94-2.51 for DD vs II+DI).
This meta-analysis suggested that the I/D polymorphism of ACE gene would be a risk factor of asthma. To further evaluate gene-to-gene and gene-to-environment interactions between polymorphisms of ACE gene and asthma risk, more studies with large groups of patients are required.
血管紧张素转换酶（ACE）基因的插入/缺失（I/D）多态性与哮喘易感性有关，但大量研究结果尚无定论。本研究旨在通过荟萃分析探讨 ACE 基因 I/D 多态性与哮喘易感性的关系。
我们检索了 Medline（Ovid）、Pubmed、中国知网（CNKI）、万方和维普数据库，检索时间截至 2010 年 3 月 12 日。采用 Revman 4.2 软件（The Cochrane Collaboration，http://www.cochrane.org）和 stata10.0（StataCorp，College Station，TX，USA，http://www.stata.com）进行统计学分析。
共纳入 18 项病例对照研究的 1946 例病例和 2152 例对照。Meta 分析结果显示，DD 纯合子携带者患哮喘的风险增加 59%，与 II 纯合子和 DI 杂合子相比[比值比（OR）=1.59，95%可信区间（CI）：1.16-2.18]。按种族亚组分析，亚洲人群中 DD 纯合子携带者哮喘风险显著增加（OR=2.02，95%CI：1.29-3.16 与 DI+II 相比），而白种人无此关联（OR=1.14，95%CI：0.76-1.72 与 DI+II 相比）。按年龄亚组分析，儿童组中 DD 纯合子携带者哮喘风险显著增加（OR=2.44，95%CI：1.36-4.38 与 II+DI 相比），而成年人无此关联（OR=1.54，95%CI：0.94-2.51 与 II+DI 相比）。
本荟萃分析提示 ACE 基因 I/D 多态性可能是哮喘的危险因素。为进一步评估 ACE 基因多态性与哮喘易感性的基因-基因和基因-环境相互作用，还需要更多大样本的研究。
