Sivrice Mehmet Emre, Akın Vural, Yasan Hasan, Hekimler Öztürk Kuyaş, Kumbul Yusuf Çağdaş
Süleyman Demirel University Faculty of Medicine, Department of Otorhinolaryngology and Head & Neck Surgery, Isparta, Türkiye.
Yüksekova State Hospital, Department of Otorhinolaryngology and Head & Neck Surgery, Hakkari, Türkiye.
Turk Arch Otorhinolaryngol. 2025 Jan 10;62(3):95-100. doi: 10.4274/tao.2024.2024-4-4.
Inflammatory processes play a role in the etiopathogenesis of chronic rhinosinusitis. Many gene polymorphisms have been associated with inflammation. In this study, we aimed to examine the relationship between angiotensin-converting enzyme insertion/deletion gene polymorphism and chronic rhinosinusitis.
Fifty-two cases with nasal polyps and 139 control patients were included in the study. Angiotensin-converting enzyme insertion/deletion gene polymorphisms, genotype, and allele distributions were determined. Results were statistically compared between groups.
Statistically significant differences were found between the chronic rhinosinusitis with nasal polyps group and the control group in terms of genotype and allele distribution (p=0.015, 0.003, respectively). There were no significant differences in genotype distribution in the chronic rhinosinusitis with nasal polyps group in terms of non-steroidal anti-inflammatory drug (NSAID) allergy, asthma, and NSAID-exacerbated respiratory disease (p=0.645, 0.660, 0.095, respectively).
We observed that the risk of chronic rhinosinusitis is higher in individuals with the deletion-deletion genotype and D allele of the angiotensin-converting enzyme insertion/deletion gene polymorphism. We believe that these results could be related to the high angiotensin-converting enzyme levels in these patients.
炎症过程在慢性鼻-鼻窦炎的病因发病机制中起作用。许多基因多态性与炎症相关。在本研究中，我们旨在探讨血管紧张素转换酶插入/缺失基因多态性与慢性鼻-鼻窦炎之间的关系。
本研究纳入了52例鼻息肉患者和139例对照患者。测定血管紧张素转换酶插入/缺失基因多态性、基因型和等位基因分布。对两组结果进行统计学比较。
鼻息肉型慢性鼻-鼻窦炎组与对照组在基因型和等位基因分布方面存在统计学显著差异（分别为p = 0.015、0.003）。鼻息肉型慢性鼻-鼻窦炎组在非甾体抗炎药（NSAID）过敏、哮喘和NSAID加重的呼吸道疾病方面，基因型分布无显著差异（分别为p = 0.645、0.660、0.095）。
我们观察到血管紧张素转换酶插入/缺失基因多态性的缺失-缺失基因型和D等位基因个体患慢性鼻-鼻窦炎的风险更高。我们认为这些结果可能与这些患者较高的血管紧张素转换酶水平有关。
