Department of Cardiology, Catholic University of Sacred Heart, Largo A Gemelli 8, 800168 Rome, Italy.
Diabetes Res Clin Pract. 2011 Jun;92(3):375-9. doi: 10.1016/j.diabres.2010.09.003. Epub 2010 Sep 28.
The aim of this study is to assess the relationship between cardiac autonomic dysfunction and increased platelet reactivity in patients with type 1 diabetes and whether alpha lipoic acid therapy (ALA) might improve both abnormalities in these patients.
Cardiac autonomic function will be assessed by heart rate variability (HRV) analysis. Platelet reactivity will be investigated by both measuring the aggregation time on the PFA-100 method and flow cytometry. HRV and platelet reactivity will be re-assessed in the patients with depressed HRV after 4 weeks from randomization to ALA or placebo.
The cardiovascular autonomic system might play a role in the modulation of platelet reactivity which is increased in diabetes. Within this framework, ALA might be found to exercise antithrombotic effects in addition to its known antioxidants properties.
Australian Clinical Trials Registry ACTRN 12610000291088.
本研究旨在评估 1 型糖尿病患者心脏自主神经功能障碍与血小板反应性增加之间的关系，以及硫辛酸治疗（ALA）是否可能改善这些患者的这两种异常。
通过心率变异性（HRV）分析评估心脏自主神经功能。通过测量 PFA-100 法的聚集时间和流式细胞术来研究血小板反应性。在随机分配到 ALA 或安慰剂 4 周后，对 HRV 降低的患者重新评估 HRV 和血小板反应性。
心血管自主神经系统可能在调节血小板反应性中发挥作用，而糖尿病患者的血小板反应性增加。在这一框架内，ALA 除了具有已知的抗氧化特性外，可能还具有抗血栓作用。
澳大利亚临床试验注册处 ACTRN 12610000291088。
