Department of Pharmaceutical Outcomes and Policy, University of Florida, Gainesville, FL, USA.
Epilepsy Behav. 2010 Nov;19(3):494-500. doi: 10.1016/j.yebeh.2010.08.030. Epub 2010 Sep 28.
Depression and suicide are increased in patients with epilepsy. The U.S. Food and Drug Administration warns that antiepileptic drugs (AEDs) are associated with increased risk of suicidality. This study examines the relationship among depression, suicidal ideation, and AEDs in a prospective cohort of 163 patients with epilepsy from a registry at the University of Florida (January 2006 to August 2008). The Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) was used to measure mood and suicidal ideation across two time points (median = 154 days). Groups included: (1) No AED Change, (2) New AED Added, (3) AED Dose Increased, (4) AED Reduced/Stopped, (5) Multiple AED Changes, and (6) Combined Any AED Change (groups 2-5 combined). No group had worsening mood or suicidal ideation. Significant improvements in proportions of depression and suicidal ideation were seen only for the No AED Change group, which differed only with the AED Dose Increased group with respect to suicidal ideation.
癫痫患者的抑郁和自杀风险增加。美国食品和药物管理局警告称，抗癫痫药物（AEDs）与自杀风险增加有关。本研究在佛罗里达大学（2006 年 1 月至 2008 年 8 月）的一个注册处前瞻性队列中对 163 名癫痫患者进行了研究，调查了抑郁、自杀意念与 AEDs 之间的关系。使用神经障碍抑郁量表癫痫版（NDDI-E）在两个时间点（中位数=154 天）测量情绪和自杀意念。分组包括：（1）无 AED 变化，（2）添加新的 AED，（3）增加 AED 剂量，（4）减少/停止 AED，（5）多种 AED 变化，（6）任意 AED 变化组合（分组 2-5 组合）。没有一个组的情绪或自杀意念恶化。只有无 AED 变化组的抑郁和自杀意念比例显著改善，仅在自杀意念方面与 AED 剂量增加组不同。
