Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark.
Neuroepidemiology. 2010;35(4):267-74. doi: 10.1159/000320245. Epub 2010 Sep 24.
Patients with multiple sclerosis (MS) may have a higher risk of cardiovascular diseases (CVD) than the general population, but data are limited.
We conducted a population-based cohort study involving Danish citizens diagnosed with MS (n = 13,963) from 1977 to 2006 and an age- and sex-matched population cohort (n = 66,407) using data on MS, arterial CVD and comorbidity from the Danish National Registry of Patients. We calculated the risk of arterial CVD for all subjects and computed adjusted incidence rate ratios (IRRs).
During the first year of follow-up, the risk of myocardial infarction (MI) was 0.2% among patients with MS (adjusted IRR = 1.84; 95% confidence interval, CI: 1.28-2.65, compared with population cohort members), whereas the 1-year risk of overall stroke was 0.3% (adjusted IRR = 1.96; 95% CI: 1.42-2.71). IRRs were 1.92 (95% CI: 1.27-2.90) for heart failure and 0.77 (95% CI: 0.42-1.39) for atrial fibrillation/flutter. During the subsequent 2-30 years of follow-up, IRRs remained elevated for overall stroke (1.23; 95% CI: 1.10-1.38) and heart failure (1.53; 95% CI: 1.37-1.71) but decreased for acute MI (1.10; 95% CI: 0.97-1.24).
In this Danish cohort, the risk of CVD among MS patients was low, but greater than that in the general population, particularly in the short term.
多发性硬化症 (MS) 患者患心血管疾病 (CVD) 的风险可能高于普通人群，但数据有限。
我们进行了一项基于人群的队列研究，纳入了 1977 年至 2006 年间丹麦被诊断为 MS 的公民（n=13963）和年龄及性别匹配的人群队列（n=66407），数据来自丹麦国家患者登记处的 MS、动脉 CVD 和合并症。我们计算了所有受试者的动脉 CVD 风险，并计算了调整后的发病率比 (IRR)。
在随访的第一年，MS 患者心肌梗死 (MI) 的风险为 0.2%（调整后的 IRR=1.84；95%置信区间，CI：1.28-2.65，与人群队列成员相比），而总体卒中的 1 年风险为 0.3%（调整后的 IRR=1.96；95% CI：1.42-2.71）。心力衰竭的 IRR 为 1.92（95% CI：1.27-2.90），心房颤动/扑动的 IRR 为 0.77（95% CI：0.42-1.39）。在随后的 2-30 年随访期间，总体卒中的 IRR 仍居高不下（1.23；95% CI：1.10-1.38）和心力衰竭（1.53；95% CI：1.37-1.71），但急性 MI 的 IRR 下降（1.10；95% CI：0.97-1.24）。
在这项丹麦队列研究中，MS 患者的 CVD 风险较低，但高于普通人群，尤其是在短期内。
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