Ashour F A, Almazroa S A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Alexandria, Egypt.
Farmaco. 1990 Nov;45(11):1207-18.
Two novel series of thiosemicarbazide derivatives were synthesized: 2-[4-(substituted thiocarbamoylhydrazinocarbonyl) phenoxymethyl]-1H-benzimidazoles and 1-benzyl-2-[4-(substituted thiocarbamoylhydrazinocarbonyl) phenoxymethyl]-1H-benzimidazoles, and cyclised to 2-[4-(4-substituted-4H-1,2,4-triazole-5-thion-3-yl)phenoxymethy ]-1H-benzimidazoles and 1-benzyl-2-[4-(4-substituted-4H-1,2,4-triazole-5- 5-thion-3-yl)phenoxymethyl]-1H-benzimidazoles, respectively. The antimicrobial activity of the prepared compounds was tested.
2-[4-(取代硫代氨基甲酰肼羰基)苯氧基甲基]-1H-苯并咪唑和1-苄基-2-[4-(取代硫代氨基甲酰肼羰基)苯氧基甲基]-1H-苯并咪唑，并分别环化生成2-[4-(4-取代-4H-1,2,4-三唑-5-硫酮-3-基)苯氧基甲基]-1H-苯并咪唑和1-苄基-2-[4-(4-取代-4H-1,2,4-三唑-5-硫酮-3-基)苯氧基甲基]-1H-苯并咪唑。测试了所制备化合物的抗菌活性。
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