Farabi Eye Research Center, Department of Neuroophthalmology, Tehran University of Medical Sciences, Tehran, Iran.
Nitric Oxide. 2010 Dec 15;23(4):332-4. doi: 10.1016/j.niox.2010.09.006. Epub 2010 Sep 25.
It has been suggested that nitric oxide (NO) has a role in ischemic retinopathies. Since retinal ischemia may develop in retinal vein occlusion, we investigated the presence of nitric oxide in the pathogenesis of central retinal vein occlusion (CRVO).
Eighteen consecutive patients with CRVO were included in this study. Aqueous humor specimens were obtained within 21 days of diagnosis. Samples of aqueous humor were also collected from 20 control patients undergoing cataract surgery. For each sample after reduction of nitrate to nitrite with vanadium chloride (VCl(3)), we used spectrophotometric method for simultaneous detection of nitrate and nitrite (NO(x)).
Mean level of aqueous humor NO(x) in CRVO and control group was 94.1±23.2 μmol/l and 55.6±11.0 μmol/l, respectively. The difference between two groups was statistically significant (p<0.0001).
Our results may support involvement of nitric oxide in the pathogenesis of CRVO.
有观点认为一氧化氮（NO）在缺血性视网膜病变中发挥作用。由于视网膜缺血可能发生在视网膜静脉阻塞中，我们研究了一氧化氮在视网膜中央静脉阻塞（CRVO）发病机制中的存在。
本研究纳入了 18 例连续的 CRVO 患者。在诊断后 21 天内获得房水标本。还从 20 名接受白内障手术的对照患者中收集房水样本。对于用五氯化钒（VCl(3)）将硝酸盐还原为亚硝酸盐后的每个样本，我们使用分光光度法同时检测硝酸盐和亚硝酸盐（NO(x)）。
CRVO 组和对照组房水中的平均 NO(x)水平分别为 94.1±23.2 μmol/l 和 55.6±11.0 μmol/l。两组间差异具有统计学意义（p<0.0001）。
我们的结果可能支持一氧化氮参与 CRVO 的发病机制。
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