视网膜静脉阻塞患者房水中的氧化应激-抗氧化平衡
Oxidant-Antioxidant Balance in the Aqueous Humor of Patients with Retinal Vein Occlusion.
作者信息
Altinisik Muhammed, Koytak Arif, Elbay Ahmet, Toklu Enes, Sezer Taha, Kocyigit Abdurrahim
机构信息
a Department of Ophthalmology , Nevsehir State Hospital , Nevsehir , Turkey.
b Faculty of Medicine, Department of Ophthalmology , Bezmialem Vakif University , Istanbul , Turkey.
出版信息
Semin Ophthalmol. 2018;33(5):675-682. doi: 10.1080/08820538.2017.1416412. Epub 2017 Dec 26.
PURPOSE
To analyze oxidative stress parameters in the aqueous humor with retinal vein occlusion.
MATERIALS AND METHODS
A total of 56 patients who underwent cataract surgery were enrolled in this study. The eyes with retinal vein occlusion were included in the study group. Aqueous humor was sampled from all patients and analyzed by an automated measurement method. Total oxidant status (TOS), total antioxidant status (TAS), and oxidative stres index (OSI) were calculated.
RESULTS
OSI was significantly higher in the study group (p = 0.04). TAS was significantly lower (p = 0.01) and OSI was significantly higher (p = 0.01) in cases with both central retinal vein occlusion and macular edema. Previous laser photocoalugation to the retina and the duration of disease had no significant effect on the levels of oxidative stress parameters.
CONCLUSION
OSI was found higher in patients with retinal vein occlusion. This increase is more significant in patients with macular edema and central retinal vein occlusion; in which TAS was also found to decrease.
目的
分析视网膜静脉阻塞患者房水中的氧化应激参数。
材料与方法
本研究共纳入56例行白内障手术的患者。视网膜静脉阻塞的患眼纳入研究组。采集所有患者的房水，并采用自动测量方法进行分析。计算总氧化剂状态（TOS）、总抗氧化剂状态（TAS）和氧化应激指数（OSI）。
结果
研究组的OSI显著更高（p = 0.04）。视网膜中央静脉阻塞合并黄斑水肿的病例中，TAS显著更低（p = 0.01），OSI显著更高（p = 0.01）。既往视网膜激光光凝治疗和病程对氧化应激参数水平无显著影响。
结论
视网膜静脉阻塞患者的OSI更高。这种升高在黄斑水肿和视网膜中央静脉阻塞患者中更为显著；同时发现这些患者的TAS也降低。
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