Experimental Neuropathophysiology Unit, Department of Pathophysiology, Medical University, Jaczewskiego 8, PL 20-090 Lublin, Poland.
Pharmacol Rep. 2010 Jul-Aug;62(4):592-607. doi: 10.1016/s1734-1140(10)70317-0.
In recent years, the concept of an immunological background of some types of epilepsy has been gaining an increasing number of supporters. The following article is an attempt to review the most significant studies that explore irregularities in patients with intractable epilepsy, search for and identify the immunological causal factors of seizures and, finally, associate these factors with particular syndromes that manifest in refractory epilepsy. We also discuss the efficacy of immunomodulatory treatment in the recognized syndromes. Last, we focus on the immunological abnormalities found in patients undergoing antiepileptic therapy with classical antiepileptic drugs as well as changes in the immune system that could be provoked by an epileptic seizure itself.
近年来，一些类型的癫痫具有免疫学背景的概念得到了越来越多的支持。本文试图回顾最重要的研究，这些研究探讨了难治性癫痫患者的异常情况，寻找并确定癫痫发作的免疫因果因素，并最终将这些因素与表现为难治性癫痫的特定综合征联系起来。我们还讨论了免疫调节治疗在已识别综合征中的疗效。最后，我们关注接受经典抗癫痫药物进行抗癫痫治疗的患者中发现的免疫学异常以及癫痫发作本身可能引起的免疫系统变化。
