Allautdin R N
Farmakol Toksikol. 1978 Jun-Aug;41(4):397-400.
In experiments with decerebrated cats subject to study was the influence of new curare-like agents of non-depolarized type of action, such as diadonium, decadonium, RGH-1106, pancuronium-bromide (pavulon) and also of paramion and mellictine on the magnitude of mono-and polysynaptic potentials of the spinal cord, the time of synaptic delay, the lability of the spinal centres and cycle of the motoneurons excitability restoration. Diadonium, decadonium, RGH-1106 and pavulon when used in 1--5-fold myoparalytic doses did not affect the bioelectric activity of the spinal cord. Mellictinum (3,5--4,5 mg/kg)) produced a rise of the monosynaptic responses amplitude by 21 per cent through inhibition of the Renshow n-cholinoreceptors cells. Paramion (0.3--1 mg/kg) suppressed monosynaptic potentials, increasing the afferent proprioceptic activity.
在对去大脑猫进行的实验中，研究对象是新型非去极化型箭毒样药物（如二胺硫磷、癸胺硫磷、RGH - 1106、泮库溴铵（巴夫龙））以及帕拉米翁和美立替丁对脊髓单突触和多突触电位幅度、突触延迟时间、脊髓中枢的易变性以及运动神经元兴奋性恢复周期的影响。二胺硫磷、癸胺硫磷、RGH - 1106和泮库溴铵以1 - 5倍肌麻痹剂量使用时，不影响脊髓的生物电活动。美立替丁（3.5 - 4.5毫克/千克）通过抑制闰绍n - 胆碱能受体细胞，使单突触反应幅度提高了21%。帕拉米翁（0.3 - 1毫克/千克）抑制单突触电位，增加传入本体感受活动。
