(+)-苦藤定 F 的全合成及绝对构型确定。

Total synthesis and absolute configuration determination of (+)-subincanadine F.

机构信息

Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PR China.

出版信息

Chem Commun (Camb). 2010 Nov 28;46(44):8436-8. doi: 10.1039/c0cc03428b. Epub 2010 Oct 1.

DOI:10.1039/c0cc03428b

PMID:20886152

Abstract

The first asymmetric synthesis of indole alkaloid (+)-subincanadine F was successfully accomplished with the uncommon 7-endo-trig stereoselective radical cyclization as the key step and its absolute configuration was thus assigned.

摘要

首次成功地完成了吲哚生物碱 (+)-subincanadine F 的不对称全合成，其中不常见的 7-endo-trig 立体选择性自由基环化反应是关键步骤，因此确定了其绝对构型。