Chen Pinhong, Cao Lidong, Li Chaozhong
Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's republic of China.
J Org Chem. 2009 Oct 2;74(19):7533-5. doi: 10.1021/jo901444e.
With chemoselective Dieckmann condensation as the key step, the protective-group-free total synthesis of (+/-)-subincanadine F was accomplished in 7 steps from the commercially available tryptamine in 33% overall yield.
以化学选择性迪克曼缩合反应为关键步骤,从市售色胺出发,经7步反应实现了(±)-subincanadine F的无保护基全合成,总收率为33%。