Mueller-Garamvölgyi Esther, Perren Aurel, Schmitt Anja
Institut für Pathologie, Universität Bern, Bern.
Ther Umsch. 2010 Oct;67(10):497-500. doi: 10.1024/0040-5930/a000084.
After decades of confusion in lymphoma classification clearness was achieved with the publication of the REAL classification 1994 and of the WHO classification 2001. The revised 4th edition 2008 features some additional new categories. The WHO classification comprises B- and T-lymphoblastic neoplasms, mature B-cell lymphomas, mature T-cell and NK-cell lymphomas and Hodgkin lymphomas. A modern diagnostic work-up of lymphomas is based on morphology, immunohistochemistry and increasingly on molecular studies. Last but not least the evaluation of all these findings by an expert haematopathologist, who collaborates closely with the treating clinicians, is essential. The aim is to give an overview of the most frequent mature B-cell lymphomas and the most important classical Hodgkin lymphomas with focus on morphology and immunohistochemistry.
在淋巴瘤分类经历数十年的混乱之后,随着1994年《REAL分类》和2001年《WHO分类》的发布,分类变得清晰起来。2008年修订的第4版有一些新增类别。WHO分类包括B和T淋巴母细胞肿瘤、成熟B细胞淋巴瘤、成熟T细胞和NK细胞淋巴瘤以及霍奇金淋巴瘤。现代淋巴瘤诊断检查基于形态学、免疫组织化学,且越来越多地基于分子研究。最后同样重要的是,由与治疗临床医生密切合作的血液病理专家对所有这些检查结果进行评估至关重要。本文旨在概述最常见的成熟B细胞淋巴瘤和最重要的经典霍奇金淋巴瘤,重点关注形态学和免疫组织化学。