一例罕见的复合性淋巴瘤病例，涉及慢性淋巴细胞白血病、滤泡性淋巴瘤和霍奇金病。

An unusual case of composite lymphoma involving chronic lymphocytic leukemia follicular lymphoma and Hodgkin disease.

作者信息

Copur M Sitki, Ledakis Peter, Novinski Daniel, Fu Kai, Hutchins Mark, Frankforter Scot, Mleczko Kris, Sanger Warren G, Chan Wing C

机构信息

Saint Francis Medical Center, Grand Island, Nebraska 68802-9804, USA

出版信息

Leuk Lymphoma. 2004 May;45(5):1071-6. doi: 10.1080/1042819032000159870.

DOI:10.1080/1042819032000159870

PMID:15291370

Abstract

Composite lymphomas constitute the presence of two different types of non-Hodgkin lymphoma or Hodgkin and non-Hodgkin lymphoma at the same anatomic site. We report an unusual case of a 73-year-old woman who initially presented with a composite lymphoma of chronic lymphocytic leukemia (CLL) and follicular lymphoma. After 5 years of follow-up and intermittent treatment, she developed Hodgkin disease with diffuse liver involvement. Biopsy of the liver showed Reed-Sternberg cells with typical morphology and immunophenotype. While fluorescent in situ hybridization (FISH) analyses for t(14;18) were positive in the lymph node tissue with follicular lymphoma, we were unable to show the same in the liver biopsy specimen. Here, we describe the clinical, morphologic, immunophenotypic, and cytogenetic features of this unusual composite lymphoma case involving CLL and follicular lymphoma, with the subsequent development of a Hodgkin lymphoma.

摘要

复合淋巴瘤是指在同一解剖部位存在两种不同类型的非霍奇金淋巴瘤或霍奇金淋巴瘤与非霍奇金淋巴瘤。我们报告了一例罕见病例，一名73岁女性最初表现为慢性淋巴细胞白血病（CLL）和滤泡性淋巴瘤的复合淋巴瘤。经过5年的随访和间断治疗，她发展为伴有弥漫性肝脏受累的霍奇金病。肝脏活检显示具有典型形态和免疫表型的里德-斯腾伯格细胞。虽然对滤泡性淋巴瘤的淋巴结组织进行的荧光原位杂交（FISH）分析显示t(14;18)呈阳性，但我们在肝脏活检标本中未能显示相同结果。在此，我们描述了这例涉及CLL和滤泡性淋巴瘤且随后发展为霍奇金淋巴瘤的罕见复合淋巴瘤病例的临床、形态学、免疫表型和细胞遗传学特征。