中国汉族人群中CD226单核苷酸多态性与系统性红斑狼疮的关联
Association of the CD226 single nucleotide polymorphism with systemic lupus erythematosus in the Chinese Han population.
作者信息
Du Y, Tian L, Shen L X, Wang F, Yu L K, Song Y, Zhu J F, Du R
机构信息
Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
出版信息
Tissue Antigens. 2011 Jan;77(1):65-7. doi: 10.1111/j.1399-0039.2010.01568.x. Epub 2010 Sep 30.
A novel non-synonymous (Gly307Ser) variant, rs763361, of the CD226 gene on chromosome 18q22 was recently shown to be associated with multiple autoimmune diseases. Taking into consideration that different autoimmune diseases may share some common pathogenic pathways, in this study we performed case-control studies to assess any genetic linkage with systemic lupus erythemtosus (SLE). An association between the Gly307Ser single nucleotide polymorphism (SNP) and susceptibility to SLE was identified. The TT genotype [odds ratio (OR) = 1.79, 95% confidence interval (CI) = 1.07-3.01, P = 0.025] and the T allele (OR = 1.34, 95% CI = 1.05-1.74, P = 0.018) of the rs763361 SNP were associated with the risk of SLE. This finding indicates that polymorphism of Gly307Ser (rs763361) in exon 7 of the CD226 gene may be associated with the development of SLE.
位于18号染色体q22区域的CD226基因的一种新型非同义（Gly307Ser）变异体rs763361，最近被证明与多种自身免疫性疾病相关。考虑到不同的自身免疫性疾病可能共享一些共同的致病途径，在本研究中，我们进行了病例对照研究，以评估与系统性红斑狼疮（SLE）的任何遗传连锁关系。我们发现Gly307Ser单核苷酸多态性（SNP）与SLE易感性之间存在关联。rs763361 SNP的TT基因型[比值比（OR）=1.79，95%置信区间（CI）=1.07 - 3.01，P = 0.025]和T等位基因（OR = 1.34，95% CI = 1.05 - 1.74，P = 0.018）与SLE风险相关。这一发现表明，CD226基因第7外显子中Gly307Ser（rs763361）的多态性可能与SLE的发生发展有关。
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