Department of Rheumatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022 Wuhan, Hubei, People's Republic of China.
Rheumatol Int. 2012 May;32(5):1299-304. doi: 10.1007/s00296-011-1796-z. Epub 2011 Feb 1.
Recent case-control studies have identified some loci that are associated with rheumatoid arthritis (RA). Among these, a single nucleotide polymorphism (SNP), Gly307Ser (rs763361), in the CD226 gene was first discovered to confer the risk of RA in populations with European and Colombian ancestry. Because the effect of genetic factors varies in different races, the association between RA and CD226 is yet to be evaluated in other non-European populations. Here, we report the significant association between CD226 and RA in a Chinese population of 423 randomly enrolled individuals. The statistical results show that the rs763361 SNP in the CD226 gene is significantly associated with RA in the Chinese population group (P (obs) = 0.005, odds ratio = 1.52). After adjusting for sex and age using multivariate logistics regression analysis, the association is still positive (P (adj) = 0.029, odds ratio = 1.45). Meta-analysis confirms the association between rs763361 and RA (overall P < 0.001, overall odds ratio = 1.12). The test of odds ratio heterogeneity also suggests that the rs763361 SNP confers the same risk of RA in both the Chinese and the Colombian populations, and indicates that rs763361 may play a more important role in non-European populations compared with the European population (P = 0.031). These results demonstrate a genetic association between the CD226 gene and RA in a Chinese Han population with a potentially greater genetic effect than in the European population.
最近的病例对照研究已经确定了一些与类风湿关节炎（RA）相关的基因位点。在这些基因中，CD226 基因中的 Gly307Ser（rs763361）单核苷酸多态性（SNP）首先被发现与欧洲和哥伦比亚人群的 RA 易感性相关。由于遗传因素的影响在不同种族之间存在差异，因此 CD226 与 RA 之间的关联尚未在其他非欧洲人群中进行评估。在这里，我们报告了 423 名随机入组的中国人群中 CD226 与 RA 之间的显著关联。统计结果表明，CD226 基因中的 rs763361 SNP 与中国人群 RA 显著相关（P（obs）= 0.005，优势比= 1.52）。使用多元逻辑回归分析调整性别和年龄后，关联仍然为正（P（adj）= 0.029，优势比= 1.45）。Meta 分析证实了 rs763361 与 RA 之间的关联（总体 P < 0.001，总体优势比= 1.12）。优势比异质性检验还表明，rs763361 SNP 在中国人群和哥伦比亚人群中赋予 RA 相同的风险，并且表明 rs763361 可能在非欧洲人群中比欧洲人群发挥更重要的作用（P = 0.031）。这些结果表明，CD226 基因与中国汉族人群 RA 之间存在遗传关联，其遗传效应可能比欧洲人群更大。
