[羟氯喹：抗磷脂综合征血栓形成表现的一种新治疗方法]

[Hydroxychloroquine: a new therapeutic approach to the thrombotic manifestations of antiphospholipid syndrome].

作者信息

Szymezak J, Ankri A, Fischer A-M, Darnige L

机构信息

Service d'hématologie biologique, hôpital européen Georges-Pompidou, AP-HP, 20-40, rue Leblanc, 75908 Paris cedex 15, France.

出版信息

Rev Med Interne. 2010 Dec;31(12):854-7. doi: 10.1016/j.revmed.2010.08.018.

DOI:10.1016/j.revmed.2010.08.018

PMID:20888088

Abstract

Studies have shown a protective effect of hydroxychloroquine on thrombosis in systemic lupus erythematosus patients. Recent in vitro studies have demonstrated that this molecule was able to restore the anticoagulant action of annexin A5, which is reduced in presence of antiphospholipid antibodies. Hydroxychloroquine use may be a new approach of the prevention of thrombosis in the antiphospholipid syndrome, which remains to be validated by well-conducted clinical trials.

摘要

研究表明，羟氯喹对系统性红斑狼疮患者的血栓形成具有保护作用。最近的体外研究表明，该分子能够恢复膜联蛋白A5的抗凝作用，而在抗磷脂抗体存在的情况下，膜联蛋白A5的抗凝作用会降低。使用羟氯喹可能是预防抗磷脂综合征血栓形成的一种新方法，这仍有待通过精心设计的临床试验来验证。