母亲子痫前期可保护早产儿免受严重早产儿视网膜病变的影响。

Maternal preeclampsia protects preterm infants against severe retinopathy of prematurity.

机构信息

Department of Pediatrics and Ophthalmology, Newborn Section, Universidade Federal do Rio Grande do Sul and Hospital de Clinicas de Porto Alegre, Porto Alegre, RS, Brazil.

出版信息

J Pediatr. 2011 Mar;158(3):372-6. doi: 10.1016/j.jpeds.2010.08.051. Epub 2010 Oct 8.

DOI:10.1016/j.jpeds.2010.08.051

PMID:20888573

Abstract

OBJECTIVE

To study the influence of maternal preeclampsia on the occurrence of retinopathy of prematurity.

STUDY DESIGN

A prospective cohort study of 324 preterm neonates with birth weight ≤ 1500 g and gestational age ≤ 32 weeks. Multiple maternal and perinatal factors were analyzed for association and confounding by multiple logistic regression analysis.

RESULTS

Mean birth weight was 1128 ± 240 g, and mean gestational age 29.7 ± 1.9 weeks. Twenty-four newborns (7.4%) had severe retinopathy of prematurity; 97 had any stage of retinopathy, and 227 had no retinopathy of prematurity. Preeclampsia and complete antenatal steroid treatment course reduced the risk for any stage of retinopathy of prematurity by 60% and 54%, respectively. Preeclampsia reduced the risk for severe retinopathy of prematurity by 80%.

CONCLUSIONS

Preeclampsia lowered the risk for occurrence of any stage and severe retinopathy of prematurity in very low birth weight infants.

摘要

目的

研究母亲子痫前期对早产儿视网膜病变发生的影响。

研究设计

对 324 例出生体重≤1500g、胎龄≤32 周的早产儿进行前瞻性队列研究。通过多因素 logistic 回归分析，分析多种母儿围产因素的关联和混杂作用。

结果

平均出生体重为 1128±240g，平均胎龄 29.7±1.9 周。24 例新生儿（7.4%）患有严重早产儿视网膜病变；97 例有任何阶段的视网膜病变，227 例无早产儿视网膜病变。子痫前期和完整的产前类固醇治疗疗程分别使任何阶段的早产儿视网膜病变的风险降低 60%和 54%。子痫前期使严重早产儿视网膜病变的风险降低了 80%。