O'Connor Maureen T, Vohr Betty R, Tucker Richard, Cashore William
Department of Pediatrics, Women and Infants' Hospital, Brown Medical School, Providence, RI 02905, USA.
J Perinatol. 2003 Dec;23(8):673-8. doi: 10.1038/sj.jp.7211008.
Retinopathy of prematurity (ROP) is a complication seen in many very low birth weight infants. Severe ROP has been called a "marker" for severe disability. The purpose of this study was to evaluate the occurrence and severity of ROP among infants < or =1250 g birth weight treated in the Special Care Nursery at Women & Infants' Hospital over a period of 7 years from 1994 to 2000.
This was a retrospective review of ROP data combined with neonatal follow-up data. Of the 1002 infants born with birth weights <1250 g, ophthalmologic data were available for 739 of 839 survivors. Analysis of variance and chi2 along with logistic regression were used to analyze outcomes.
An increase in the overall occurrence of ROP was identified (40% to 54% linear trend, p=0.007). The occurrence of threshold ROP ranged from 2% to 5% (NS). Infants at greatest risk of ROP were those micropremies with birth weights <750 g (p<0.001).
Severe ROP continues to be a significant morbidity among infants <750 g.
早产儿视网膜病变（ROP）是许多极低出生体重儿出现的一种并发症。严重ROP被称为严重残疾的“标志”。本研究的目的是评估1994年至2000年7年间在妇女和婴儿医院特别护理病房接受治疗的出生体重≤1250g的婴儿中ROP的发生率和严重程度。
这是一项对ROP数据与新生儿随访数据相结合的回顾性研究。在1002例出生体重<1250g的婴儿中，839例幸存者中有739例有眼科数据。采用方差分析、卡方检验以及逻辑回归分析结果。
确定ROP的总体发生率有所增加（线性趋势为40%至54%，p=0.007）。阈值ROP的发生率在2%至5%之间（无显著性差异）。ROP风险最高的婴儿是那些出生体重<750g的超低体重儿（p<0.001）。
严重ROP仍然是出生体重<750g婴儿的一种重要发病情况。
